Identification and analysis of mutational hotspots in oncogenes and tumour suppressors | Zendy

Hanadi M. Baeissa | Zendy; Graeme Benstead-Hume | Zendy; Christopher Richardson | Zendy; Frances M. G. Pearl | Zendy

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Identification and analysis of mutational hotspots in oncogenes and tumour suppressors

Author(s) -

Hanadi M. Baeissa,

Graeme Benstead-Hume,

Christopher Richardson,

Frances M. G. Pearl

Publication year - 2017

Publication title -

oncotarget

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.373

H-Index - 127

ISSN - 1949-2553

DOI - 10.18632/oncotarget.15514

Subject(s) - missense mutation , genetics , mutation , biology , phenotype , indel , protein function , cancer , exome sequencing , suppressor , computational biology , gene , genotype , single nucleotide polymorphism

The key to interpreting the contribution of a disease-associated mutation in the development and progression of cancer is an understanding of the consequences of that mutation both on the function of the affected protein and on the pathways in which that protein is involved. Protein domains encapsulate function and position-specific domain based analysis of mutations have been shown to help elucidate their phenotypes.

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