Oncogenic mechanisms of Lin28 in breast cancer: new functions and therapeutic opportunities | Zendy

Hanchu Xiong | Zendy; Wenhe Zhao | Zendy; Ji Wang | Zendy; Benjamin J. Seifer | Zendy; Chenyang Ye | Zendy; Yongxia Chen | Zendy; Yunlu Jia | Zendy; Cong Chen | Zendy; Jianguo Shen | Zendy; Linbo Wang | Zendy; Xinbing Sui | Zendy; Jichun Zhou | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Oncogenic mechanisms of Lin28 in breast cancer: new functions and therapeutic opportunities

Author(s) -

Hanchu Xiong,

Wenhe Zhao,

Ji Wang,

Benjamin J. Seifer,

Chenyang Ye,

Yongxia Chen,

Yunlu Jia,

Cong Chen,

Jianguo Shen,

Linbo Wang,

Xinbing Sui,

Jichun Zhou

Publication year - 2017

Publication title -

oncotarget

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.373

H-Index - 127

ISSN - 1949-2553

DOI - 10.18632/oncotarget.14891

Subject(s) - medicine , breast cancer , cancer , metastasis , oncology , lin28 , cancer research , biology , biochemistry , embryonic stem cell , induced pluripotent stem cell , gene

The RNA binding protein Lin28 is best known for the critical role in cell development, recent researches also have implied its oncogenic function in various human cancers, including breast cancer. Specifically, aberrant Lin28 participates in multiple pathological processes, such as proliferation, metastasis, radiotherapy and chemotherapy resistance, metabolism, immunity and inflammation as well as stemness. In this review, we summarize the let-7-dependent and let-7-independent mechanism regulated by Lin28, focusing on its relation with tumor hallmarks in breast cancer, and subsequently discuss our present knowledge of Lin28 to develop a molecular-based therapeutic strategy against breast cancer.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research