Sex chromosome abnormalities and psychiatric diseases | Zendy

Xinzhu Zhang | Zendy; Jian Yang | Zendy; Yuhong Li | Zendy; Xin Ma | Zendy; Rena Li | Zendy

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Sex chromosome abnormalities and psychiatric diseases

Author(s) -

Xinzhu Zhang,

Jian Yang,

Yuhong Li,

Xin Ma,

Rena Li

Publication year - 2016

Publication title -

oncotarget

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.373

H-Index - 127

ISSN - 1949-2553

DOI - 10.18632/oncotarget.13962

Subject(s) - medicine , psychiatry , genetics , bioinformatics , biology

Excesses of sex chromosome abnormalities in patients with psychiatric diseases have recently been observed. It remains unclear whether sex chromosome abnormalities are related to sex differences in some psychiatric diseases. While studies showed evidence of susceptibility loci over many sex chromosomal regions related to various mental diseases, others demonstrated that the sex chromosome aneuploidies may be the key to exploring the pathogenesis of psychiatric disease. In this review, we will outline the current evidence on the interaction of sex chromosome abnormalities with schizophrenia, autism, ADHD and mood disorders.

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