The crosstalk between lncRNA and microRNA in cancer metastasis: orchestrating the epithelial-mesenchymal plasticity | Zendy

Mingxin Cao | Zendy; Yaping Jiang | Zendy; Yaling Tang | Zendy; Xinhua Liang | Zendy

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The crosstalk between lncRNA and microRNA in cancer metastasis: orchestrating the epithelial-mesenchymal plasticity

Author(s) -

Mingxin Cao,

Yaping Jiang,

Yaling Tang,

Xinhua Liang

Publication year - 2016

Publication title -

oncotarget

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.373

H-Index - 127

ISSN - 1949-2553

DOI - 10.18632/oncotarget.13957

Subject(s) - microrna , metastasis , competing endogenous rna , china , medicine , epithelial–mesenchymal transition , crosstalk , cancer , oncology , long non coding rna , biology , gene , downregulation and upregulation , genetics , geography , physics , archaeology , optics

Noncoding RNAs (ncRNAs) have been demonstrated to closely associate with gene regulation and encompass the well-known microRNAs (miRNAs), as well as the most recently acknowledged long noncoding RNAs (lncRNAs). Current evidence indicates that lncRNAs can interact with miRNAs and these interactions play crucial roles in cancer metastasis, through regulating critical events especially the epithelial-mesenchymal transition (EMT). This review summarizes the types of lncRNA-miRNA crosstalk identified to-date and discusses their influence on the epithelial-mesenchymal plasticity and clinical metastatic implication.

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