Endothelial cells microparticle-associated protein disulfide isomerase promotes platelet activation in metabolic syndrome | Zendy

Guanqi Fan | Zendy; Ran-Ran Qin | Zendy; Yihui Li | Zendy; Dai-jun Song | Zendy; Tongshuai Chen | Zendy; Wei Zhang | Zendy; Ming Zhong | Zendy; Yun Zhang | Zendy; Yanqiu Xing | Zendy; Zhihao Wang | Zendy

Open Access

Endothelial cells microparticle-associated protein disulfide isomerase promotes platelet activation in metabolic syndrome

Author(s) -

Guanqi Fan,

Ran-Ran Qin,

Yihui Li,

Dai-jun Song,

Tongshuai Chen,

Wei Zhang,

Ming Zhong,

Yun Zhang,

Yanqiu Xing,

Zhihao Wang

Publication year - 2016

Publication title -

oncotarget

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.373

H-Index - 127

ISSN - 1949-2553

DOI - 10.18632/oncotarget.13081

Subject(s) - microparticle , protein disulfide isomerase , platelet , platelet activation , medicine , chemistry , biochemistry , microbiology and biotechnology , cancer research , enzyme , immunology , biology , astrobiology

Metabolic syndrome (MetS) is a common challenge in the world, and the platelet activation is enhanced in MetS patients. However, the fundamental mechanism that underlies platelet activation in MetS remains incompletely understood. Endothelial cells are damaged seriously in MetS patients, then they release more endothelial microparticles (EMPs). After all, whether the EMPs participate in platelet activation is still obscure. If they were, how did they work?

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