ISG15 in the tumorigenesis and treatment of cancer: An emerging role in malignancies of the digestive system | Zendy

Chaohui Zuo | Zendy; Xinyi Sheng | Zendy; Min Ma | Zendy; Man Xia | Zendy; Linda Ouyang | Zendy

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ISG15 in the tumorigenesis and treatment of cancer: An emerging role in malignancies of the digestive system

Author(s) -

Chaohui Zuo,

Xinyi Sheng,

Min Ma,

Man Xia,

Linda Ouyang

Publication year - 2016

Publication title -

oncotarget

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.373

H-Index - 127

ISSN - 1949-2553

DOI - 10.18632/oncotarget.11911

Subject(s) - isg15 , carcinogenesis , ubiquitin , immune system , cancer research , cancer , biology , cancer cell , microbiology and biotechnology , gene , immunology , genetics

The interferon-stimulated gene 15 ubiquitin-like modifier (ISG15) encodes an IFN-inducible, ubiquitin-like protein. The ISG15 protein forms conjugates with numerous cellular proteins that are involved in a multitude of cellular functions, including interferon-induced immune responses and the regulation of cellular protein turnover. The expression of ISG15 and ISG15-mediated conjugation has been implicated in a wide range of human tumors and cancer cell lines, but the roles of ISG15 in tumorigenesis and responses to anticancer treatments remain largely unknown. In this review, we discuss the findings of recent studies with regard to the role of ISG15 pathways in cancers of the digestive system.

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