Open AccessTargeting TOR dependence in cancer
Author(s) -
Matthew R. Janes,
David A. Fruman
Publication year - 2010
Publication title -
oncotarget
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.373
H-Index - 127
ISSN - 1949-2553
DOI - 10.18632/oncotarget.110
Subject(s) - tolerability , medicine , cancer , cancer therapy , cancer research , cancer cell , bioinformatics , oncology , computational biology , biology , adverse effect
A challenge in cancer therapy has been to identify targets whose function is essential for survival of malignant cells but not normal cells. This Perspective discusses recent evidence that novel inhibitors of the kinase TOR can provide an unprecedented balance of anti-cancer efficacy and tolerability.
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