The tumor suppressor p53 connects ribosome biogenesis to cell cycle control: a double-edged sword | Zendy

Michael Hölzel | Zendy; Kaspar Burger | Zendy; Bastian Mühl | Zendy; Mathias Orban | Zendy; Markus Kellner | Zendy; Dirk Eick | Zendy

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The tumor suppressor p53 connects ribosome biogenesis to cell cycle control: a double-edged sword

Author(s) -

Michael Hölzel,

Kaspar Burger,

Bastian Mühl,

Mathias Orban,

Markus Kellner,

Dirk Eick

Publication year - 2010

Publication title -

oncotarget

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.373

H-Index - 127

ISSN - 1949-2553

DOI - 10.18632/oncotarget.107

Subject(s) - ribosome biogenesis , biogenesis , microbiology and biotechnology , cell cycle , dna damage , cell cycle checkpoint , biology , programmed cell death , genome instability , ribosome , suppressor , cell , cancer research , genetics , rna , dna , apoptosis , cancer , gene

Since its first description more than 30 years ago p53 has become a paradigm for a protein with versatile functions. P53 sensitizes a large variety of genetic alterations and has been entitled the guardian of the genome. Stabilization of p53 upon DNA damage is accompanied by a complex pattern of modifications, which ascertain the cellular response either in the direction of a reversible or irreversible cell cycle arrest or programmed cell death. More recently it became evident that p53 also responds to non-genotoxic cell stress, in particular if ribosome biogenesis is affected.

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