P-Cadherin (CDH3) is overexpressed in colorectal tumors and has potential as a serum marker for colorectal cancer monitoring | Zendy

H. M. C. Shantha Kumara | Zendy; Geoffrey Bellini | Zendy; Otávia L. Caballero | Zendy; Sonali A. Herath | Zendy; Tao Su | Zendy; Aqeel Ahmed | Zendy; Linda Njoh | Zendy; Vesna Cekic | Zendy; Richard L. Whelan | Zendy

Open Access

P-Cadherin (CDH3) is overexpressed in colorectal tumors and has potential as a serum marker for colorectal cancer monitoring

Author(s) -

H. M. C. Shantha Kumara,

Geoffrey Bellini,

Otávia L. Caballero,

Sonali A. Herath,

Tao Su,

Aqeel Ahmed,

Linda Njoh,

Vesna Cekic,

Richard L. Whelan

Publication year - 2017

Publication title -

oncoscience

Language(s) - English

Resource type - Journals

ISSN - 2331-4737

DOI - 10.18632/oncoscience.370

Subject(s) - colorectal cancer , cadherin , cancer , real time polymerase chain reaction , medicine , pathology , biology , cell , gene , biochemistry , genetics

Placental-Cadherin (CDH3) is a cell adhesion molecule vital to cellular localization and tissue integrity. It is highly expressed in the placenta (PLC)and is overexpressed by many types of cancer. P-cadherin levels in colorectal cancer (CRC) remains poorly characterized. This study's purpose was to determine P-cadherin expression in CRC and normal tissues and to assess plasma CDH3 levels in order to determine the relationship, if any, between cancer stage, P-cadherin expression and plasma CDH3 levels.

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