KLF8: so different in ovarian and breast cancer | Zendy

Jihe Zhao | Zendy

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KLF8: so different in ovarian and breast cancer

Author(s) -

Jihe Zhao

Publication year - 2014

Publication title -

oncoscience

Language(s) - English

Resource type - Journals

ISSN - 2331-4737

DOI - 10.18632/oncoscience.34

Subject(s) - ovarian cancer , breast cancer , complementary dna , cancer research , cancer , mcf 7 , microarray analysis techniques , ectopic expression , microarray , cell culture , oncology , human breast , gene , medicine , gene expression , biology , genetics

At the time when KLF8 was cloned as a FAK-induced gene, nothing but a partial mRNA sequence of it was known. During the study into the role of KLF8 in FAK-promoted cell cycle progression [1], we noticed that KLF8 expression is upregulated in some human cancer cell lines particularly breast and ovarian cancer types as demonstrated by the Stanford University cDNA microarray database for the NCI-60 human cancer cell line panel. Meanwhile, we also obtained unpublished data showing that ectopic overexpression of KLF8 prolongs survival of various cell types in nutrient-deprived or over-consumed medium. These observations pointed to a potential role of KLF8 in cancer.

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