6-Bromoindirubin-3’-oxime (6BIO) prevents myocardium from aging by inducing autophagy | Zendy

Donghao Guo | Zendy; Lizhen Cheng | Zendy; Yun Shen | Zendy; Wei Li | Zendy; Qinjie Li | Zendy; Yuan Zhong | Zendy; Ya Miao | Zendy

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6-Bromoindirubin-3’-oxime (6BIO) prevents myocardium from aging by inducing autophagy

Author(s) -

Donghao Guo,

Lizhen Cheng,

Yun Shen,

Wei Li,

Qinjie Li,

Yuan Zhong,

Ya Miao

Publication year - 2020

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.202253

Subject(s) - autophagy , oxime , chemistry , microbiology and biotechnology , pharmacology , medicine , biology , biochemistry , apoptosis

6-Bromoindirubin-3'-oxime (6BIO) is a novel small molecule that exerts positive effects on several age-related alterations. However, the anti-aging effects of 6BIO on the aging heart remain unknown. Herein, we aim to investigate the effects of 6BIO on the myocardium and its underlying mechanism in vivo and vitro. Following 6BIO treatment, an increased p53 contents, a reduced p16 and β-gal levels, and attenuation of cardiac fibrosis were observed, suggesting 6BIO retarded aging of cardiomyocytes. As observed, 6BIO reduced p62 contents, elevated the levels of Beclin-1 and the ratio of LC3II/I, indicating the induction of autophagy, while the reduction of the accumulation of ROS indicated 6BIO alleviated oxidative stress. In addition, 6BIO treatment inhibited both GSK3β signaling and mTOR signaling. 6BIO might be a promising agent for preventing myocardium from aging.

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