Coicis semen protects against focal cerebral ischemia-reperfusion injury by inhibiting oxidative stress and promoting angiogenesis via the TGFβ/ALK1/Smad1/5 signaling pathway | Zendy

Jin Du | Zendy; Guobing Yin | Zendy; Yida Hu | Zendy; Si Shi | Zendy; Jiazhen Jiang | Zendy; Xiaoyan Song | Zendy; Zhetao Zhang | Zendy; Zeyuan Wei | Zendy; Chaoliang Tang | Zendy; Haiyan Lyu | Zendy

Open Access

Coicis semen protects against focal cerebral ischemia-reperfusion injury by inhibiting oxidative stress and promoting angiogenesis via the TGFβ/ALK1/Smad1/5 signaling pathway

Author(s) -

Jin Du,

Guobing Yin,

Yida Hu,

Si Shi,

Jiazhen Jiang,

Xiaoyan Song,

Zhetao Zhang,

Zeyuan Wei,

Chaoliang Tang,

Haiyan Lyu

Publication year - 2020

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.202194

Subject(s) - oxidative stress , angiogenesis , ischemia , pharmacology , medicine

Ischemic stroke is a devastating disease that causes long-term disability. However, its pathogenesis is unclear, and treatments for ischemic stroke are limited. Recent studies indicate that oxidative stress is involved in the pathological progression of ischemic stroke and that angiogenesis participates in recovery from ischemic stroke. Furthermore, previous studies have shown that Coicis Semen has antioxidative and anti-inflammatory effects in a variety of diseases. In the present study, we investigated whether Coicis Semen has a protective effect against ischemic stroke and the mechanism of this protective effect.

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