Dihydromyricetin promotes longevity and activates the transcription factors FOXO and AOP in Drosophila | Zendy

Xiaolan Fan | Zendy; Yao Zeng | Zendy; Ziqiang Fan | Zendy; Liang Cui | Zendy; Wenhao Song | Zendy; Qi Wu | Zendy; Yue Gao | Zendy; Deying Yang | Zendy; Xueping Mao | Zendy; Bo Zeng | Zendy; Mingwang Zhang | Zendy; Qingyong Ni | Zendy; Yán Li | Zendy; Tao Wang | Zendy; Diyan Li | Zendy; Mingyao Yang | Zendy

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Dihydromyricetin promotes longevity and activates the transcription factors FOXO and AOP in Drosophila

Author(s) -

Xiaolan Fan,

Yao Zeng,

Ziqiang Fan,

Liang Cui,

Wenhao Song,

Qi Wu,

Yue Gao,

Deying Yang,

Xueping Mao,

Bo Zeng,

Mingwang Zhang,

Qingyong Ni,

Yán Li,

Tao Wang,

Diyan Li,

Mingyao Yang

Publication year - 2020

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.202156

Subject(s) - longevity , transcription factor , microbiology and biotechnology , drosophila (subgenus) , chemistry , biology , genetics , gene

Drugs or compounds have been shown to promote longevity in various approaches. We used Drosophila to explore novel natural compounds can be applied to anti-aging. Here we reported that a flavonoid named Dihydromyricetin can increase stress that tolerance and lipid levels, slow down gut dysfunction and extend Drosophila lifespan. Dihydromyricetin can also lessen pERK and pAKT signaling, consequently activating FOXO and AOP to modulate longevity. Our results suggested that DHM could be used as an effective compound for anti-aging intervention, which could likely be applied to both mammals and humans.

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