GDF11 induces mild hepatic fibrosis independent of metabolic health | Zendy

Jan Fröhlich | Zendy; Kristína Kovačovicová | Zendy; Tommaso Mazza | Zendy; Maria Rita Emma | Zendy; Daniela Cabibi | Zendy; Michelangelo Foti | Zendy; Cyril Sobolewski | Zendy; Jude A. Oben | Zendy; Marion Peyrou | Zendy; Francesc Villarroya | Zendy; Maurizio Soresi | Zendy; Rita Rezzani | Zendy; Melchiorre Cervello | Zendy; Francesca Bonomini | Zendy; Anna Alisi | Zendy; Manlio Vinciguerra | Zendy

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GDF11 induces mild hepatic fibrosis independent of metabolic health

Author(s) -

Jan Fröhlich,

Kristína Kovačovicová,

Tommaso Mazza,

Maria Rita Emma,

Daniela Cabibi,

Michelangelo Foti,

Cyril Sobolewski,

Jude A. Oben,

Marion Peyrou,

Francesc Villarroya,

Maurizio Soresi,

Rita Rezzani,

Melchiorre Cervello,

Francesca Bonomini,

Anna Alisi,

Manlio Vinciguerra

Publication year - 2020

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.104182

Subject(s) - steatohepatitis , steatosis , fatty liver , medicine , fibrosis , hepatic stellate cell , hepatic fibrosis , endocrinology , pathological , disease

Growth Differentiation Factor 11 (GDF11) is an anti-aging factor, yet its role in liver diseases is not established. We evaluated the role of GDF11 in healthy conditions and in the transition from non-alcoholic fatty liver disease (NAFLD) to non-alcoholic steatohepatitis (NASH).

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