The DLG1-AS1/miR-497/YAP1 axis regulates papillary thyroid cancer progression | Zendy

Yong Huang | Zendy; Kewei Zhang | Zendy; Yinghua Li | Zendy; Yuyin Dai | Zendy; Hongguang Zhao | Zendy

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The DLG1-AS1/miR-497/YAP1 axis regulates papillary thyroid cancer progression

Author(s) -

Yong Huang,

Kewei Zhang,

Yinghua Li,

Yuyin Dai,

Hongguang Zhao

Publication year - 2020

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.104121

Subject(s) - papillary thyroid cancer , thyroid cancer , cancer research , medicine , yap1 , cancer , biology , pathology , gene , genetics , transcription factor

The long non-coding RNA (lncRNA), DLG1-AS1, is upregulated in papillary thyroid cancer (PTC) tissues and cell lines. Here, we found that increased expression of DLG1-AS1 caused lymph node metastasis and advanced tumor-node-metastasis (TNM) stage. DLG1-AS1 knockdown inhibited proliferation, invasion, and migration of PTC cells, and impaired tumorigenesis in vivo in mouse xenografts. DLG1-AS1 functions as a competing endogenous RNA (ceRNA) for miR-497. Further investigation revealed that DLG1-AS1 regulated yes-associated protein 1 (YAP1; a known target of miR-497) by competitively binding to miR-497. Moreover, inhibition of miR-497 abrogated the inhibitory effects of DLG1-AS1 depletion on PTC cells. These findings demonstrate that the DLG1-AS1-miR-497-YAP1 axis promotes the growth and metastasis of PTC by forming a ceRNA network.

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