Identification of immune-related LncRNA for predicting prognosis and immunotherapeutic response in bladder cancer | Zendy

Yucai Wu | Zendy; Lei Zhang | Zendy; Shiming He | Zendy; Bao Guan | Zendy; Anbang He | Zendy; KunLin Yang | Zendy; Yanqing Gong | Zendy; Xuesong Li | Zendy; Liqun Zhou | Zendy

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Identification of immune-related LncRNA for predicting prognosis and immunotherapeutic response in bladder cancer

Author(s) -

Yucai Wu,

Lei Zhang,

Shiming He,

Bao Guan,

Anbang He,

KunLin Yang,

Yanqing Gong,

Xuesong Li,

Liqun Zhou

Publication year - 2020

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.104115

Subject(s) - immune system , immunotherapy , gene signature , oncology , proportional hazards model , immune checkpoint , bladder cancer , cd8 , survival analysis , multivariate analysis , biology , medicine , cancer research , immunology , cancer , gene , gene expression , genetics

Long noncoding RNAs (lncRNAs) have multiple functions in the cancer immunity response and the tumor microenvironment. To investigate the immune-related lncRNA (IRlncRNA) signature for predicting prognosis and immunotherapeutic response in bladder cancer (BLCA), we extracted BLCA data from The Cancer Genome Atlas (TCGA) database. Finally, a total of 405 cases were enrolled and 8 prognostic IRlncRNAs ( MIR181A2HG, AC114730.3 , LINC00892 , PTPRD-AS1, LINC01013, MRPL23-AS1, LINC01395 , AC002454.1) were identified in the training set. Risk scores were calculated to divide patients into high-risk and low-risk groups, and the high-risk patients tended to have a poor overall survival (OS). Multivariate Cox regression analysis confirmed that the IRlncRNA signature could be an independent prognostic factor. The results were subsequently confirmed in the validating set. Additionally, this 8-IRlncRNA classifier was related to recurrence free survival (RFS) of BLCA. Functional characterization revealed this signature mediated immune-related phenotype. This signature was also associated with immune cell infiltration (i.e., macrophages M0, M2, Tregs, CD8 T cells, and neutrophils) and immune checkpoint inhibitors (ICIs) immunotherapy-related biomarkers [mismatch repair (MMR) genes, tumor mutation burden (TMB) and immune checkpoint genes]. The present study highlighted the value of the 8-IRlncRNA signature as a predictor of prognosis and immunotherapeutic response in BLCA.

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