miR-205 inhibits the development of hypertrophic scars by targeting THBS1 | Zendy

Dongwen Jiang | Zendy; Bingyu Guo | Zendy; Feng Lin | Zendy; Shixiu Lin | Zendy; Kai Tao | Zendy

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miR-205 inhibits the development of hypertrophic scars by targeting THBS1

Author(s) -

Dongwen Jiang,

Bingyu Guo,

Feng Lin,

Shixiu Lin,

Kai Tao

Publication year - 2020

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.104044

Subject(s) - hypertrophic scar , scars , thrombospondin 1 , western blot , microrna , apoptosis , thrombospondin , chemistry , cancer research , microbiology and biotechnology , medicine , biology , pathology , angiogenesis , gene , biochemistry , metalloproteinase , matrix metalloproteinase

Increasing evidence shows that miRNAs are involved in the growth and development of hypertrophic scars. However, the specific mechanism of miR-205 is unclear. Here, we investigated the relationship between miR-205, thrombospondin 1 (THBS1) expression, and hypertrophic scars, and showed that miR-205 inhibits cell proliferation and migration and induces apoptosis. Double luciferase analysis, Western blot, and real-time polymerase chain reaction showed that miR-205 downregulates THBS1 expression and activity. Compared to the control group, miR-205 inhibited hypertrophic scar development. Our findings contribute to a better understanding of the miR-205-THBS1 pathway as a promising therapeutic target for reducing hypertrophic scars.

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