Identification of the novel Np17 oncogene in human leukemia | Zendy

Bowen Wu | Zendy; Yichao Gan | Zendy; Ying Xu | Zendy; Zhaoxing Wu | Zendy; Ganyu Xu | Zendy; Ping Wang | Zendy; Chen Wang | Zendy; Zhipeng Meng | Zendy; Mengyuan Li | Zendy; Jiawei Zhang | Zendy; Haifeng Zhuang | Zendy; Xuzhao Zhang | Zendy; Linlin Yang | Zendy; Jinfan Li | Zendy; Xiaoxian Gan | Zendy; Xiaofang Yu | Zendy; Wendong Huang | Zendy; Ying Gu | Zendy; Rongzhen Xu | Zendy

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Identification of the novel Np17 oncogene in human leukemia

Author(s) -

Bowen Wu,

Yichao Gan,

Ying Xu,

Zhaoxing Wu,

Ganyu Xu,

Ping Wang,

Chen Wang,

Zhipeng Meng,

Mengyuan Li,

Jiawei Zhang,

Haifeng Zhuang,

Xuzhao Zhang,

Linlin Yang,

Jinfan Li,

Xiaoxian Gan,

Xiaofang Yu,

Wendong Huang,

Ying Gu,

Rongzhen Xu

Publication year - 2020

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.103808

Subject(s) - myeloid leukemia , leukemia , oncogene , cancer research , exon , gene knockdown , biology , mdm2 , gene , homologous chromosome , microbiology and biotechnology , genetics , cell cycle

We previously defined the HERV-K Np9 as a viral oncogene. Here we report the discovery of a novel oncogene, Np17, which is homologous to the viral Np9 gene and predominantly present in Hominoidea. Np17 is located on chromosome 8, consists of 7 exons, and encodes a 16.8kDa nuclear protein with149 amino-acid residue. Functionally, knockdown of Np17 induced growth inhibition of leukemia cells, whereas enforced expression of Np17 promoted growth of leukemia cells in vitro and in vivo. In human leukemia, Np17 was detected in 59.65% (34/57) of acute myeloid leukemia (AML) patients examined and associated with refractory/relapsed AML. Mechanistically, Np17 decreased p53 levels and its mechanism might be involved in recruiting nuclear MDM2 to p53 for ubiquitin-mediated degradation. These findings reveal that Np17 is a novel oncogene associated with refractory/relapsed leukemia.

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