SNAI1 is a prognostic biomarker and correlated with immune infiltrates in gastrointestinal cancers | Zendy

Jiaying Fang | Zendy; Zan Ding | Zendy

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SNAI1 is a prognostic biomarker and correlated with immune infiltrates in gastrointestinal cancers

Author(s) -

Jiaying Fang,

Zan Ding

Publication year - 2020

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.103667

Subject(s) - snai1 , immunohistochemistry , gastrointestinal cancer , medicine , immune system , oncology , biomarker , clinical significance , infiltration (hvac) , epithelial–mesenchymal transition , cancer research , pathology , cancer , immunology , biology , colorectal cancer , metastasis , biochemistry , physics , thermodynamics

Epithelial-mesenchymal transition (EMT)-related genes play an important role in immunosuppression. However, the correlations of EMT-related genes to prognosis and tumor-infiltrating lymphocytes in different cancers remain unclear. TCGA, GEO databases were used to analyze the expression, prognosis, and immune infiltration of EMT markers in cancer. RT-qPCR, immunohistochemistry, and western blot were used to analysis the expression and prognosis of SNAI1 in gastrointestinal cancers. High SNAI1 expression was closely related with poorer overall survival in gastrointestinal cancers in TCGA cohort. High SNAI1 expression was closely related with poorer overall survival in gastrointestinal cancers, and was validated in GEO database. Simultaneously, high expression of SNAI1 correlates with clinical relevance of gastric cancer. Moreover, SNAI1 expression was associated with tumor-infiltrating immune cells in gastrointestinal cancers. In addition, RT-qPCR, immunohistochemistry, and western blot showed SNAI1 expression was higher in gastrointestinal cancers compared to the normal tissues. Finally, high SNAI1 expression was closely related with poorer overall survival and correlates with clinical relevance of gastrointestinal cancers in an independent validation cohort. In summary, the results approaches to suggest that SNAI1 can be used as a prognostic biomarker for determining prognosis and immune infiltration in gastrointestinal cancers.

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