Circulating exosomal miR-144-3p inhibits the mobilization of endothelial progenitor cells post myocardial infarction via regulating the MMP9 pathway | Zendy

Yihai Liu | Zendy; Jiamin Xu | Zendy; Rong Gu | Zendy; Li Zhu | Zendy; Kun Wang | Zendy; Yu Qi | Zendy; Xuan Sun | Zendy; Jun Xie | Zendy; Lian Wang | Zendy; Biao Xu | Zendy; Lina Kang | Zendy

Open Access

Circulating exosomal miR-144-3p inhibits the mobilization of endothelial progenitor cells post myocardial infarction via regulating the MMP9 pathway

Author(s) -

Yihai Liu,

Jiamin Xu,

Rong Gu,

Li Zhu,

Kun Wang,

Yu Qi,

Xuan Sun,

Jun Xie,

Lian Wang,

Biao Xu,

Lina Kang

Publication year - 2020

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.103651

Subject(s) - mobilization , progenitor cell , mmp9 , myocardial infarction , microbiology and biotechnology , medicine , chemistry , cancer research , cardiology , stem cell , biology , downregulation and upregulation , political science , biochemistry , gene , law

The angiogenesis post myocardial infarction (MI) is compromised in diabetes. MiR-144-3p is reported to be highly expressed in circulating exosomes of diabetic patients, implying its role in diabetic complications. However, whether circulating exosomes and enriched miR-144-3p are involved in the impaired neovascularization in diabetes and the underlying mechanism is unclear.

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