Identification of cardiovascular health gene variants related to longevity in a Chinese population | Zendy

Li Zhang | Zendy; Chen Bai | Zendy; Chao Nie | Zendy; Xiaoquan Zhu | Zendy; Huiping Yuan | Zendy; Liang Sun | Zendy; Qi Zhou | Zendy; Xiaoling Li | Zendy; Xuan Xian | Zendy; Fan Yang | Zendy; GuoFang Pang | Zendy; Yuan Lv | Zendy; Xiaolin Ni | Zendy; Caiyou Hu | Zendy; Ze Yang | Zendy

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Identification of cardiovascular health gene variants related to longevity in a Chinese population

Author(s) -

Li Zhang,

Chen Bai,

Chao Nie,

Xiaoquan Zhu,

Huiping Yuan,

Liang Sun,

Qi Zhou,

Xiaoling Li,

Xuan Xian,

Fan Yang,

GuoFang Pang,

Yuan Lv,

Xiaolin Ni,

Caiyou Hu,

Ze Yang

Publication year - 2020

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.103396

Subject(s) - longevity , kegg , genome wide association study , disease , biology , genetic association , gene , genetics , medicine , bioinformatics , single nucleotide polymorphism , gene ontology , genotype , gene expression

Cardiovascular disease (CVD) is one of the most important causes of human death, but no attention has been paid to cardiovascular health genes related to healthy longevity. Therefore, we developed a cohort study to explore such genes in healthy, long-lived Chinese subjects. A total of 13275 healthy elderly people were enrolled, including 5107 healthy long-lived individuals and 8168 age-matched control individuals with low CVD risk. Using a combination of whole-exome sequencing (WES) and genome-wide association studies (GWAS), we identified 2 genetic variants (TFPI rs7586970 T, p=0.013, OR=1.100. ADAMTS7 rs3825807 A, p=0.017, OR=1.198) associated with healthy lipid metabolism and longevity. Furthermore, we showed that an interaction among TFPI rs7586970, ADAMTS7 rs3825807 and APOE ɛ3 maintained normal blood lipid levels in centenarians by stratified analysis of CVD risk factors. Finally, through biological function analysis, we revealed clues regarding the mechanism of factor related to cardiovascular health (FCH) such as lipids and longevity. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis indicated that the two variants above may be associated with longevity via FCH lipid metabolism pathways. From a meta-analysis of venous thrombosis patients, we unexpectedly found that rs7586970 T is associated with both longevity and protection against vascular disease.

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