circKIF4A sponges miR-127 to promote ovarian cancer progression | Zendy

Shunliang Sheng | Zendy; Yi Hu | Zendy; Furong Yu | Zendy; Wenjuan Tong | Zendy; Shufen Wang | Zendy; Yanlin Cai | Zendy; Jiayu Zhu | Zendy

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circKIF4A sponges miR-127 to promote ovarian cancer progression

Author(s) -

Shunliang Sheng,

Yi Hu,

Furong Yu,

Wenjuan Tong,

Shufen Wang,

Yanlin Cai,

Jiayu Zhu

Publication year - 2020

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.103389

Subject(s) - ovarian cancer , gene knockdown , cancer , competing endogenous rna , cancer research , biology , tumor progression , biomarker , downregulation and upregulation , gene , long non coding rna , genetics

Ovarian cancer is a major gynecologic cancer and common cause of gynecologic cancer death worldwide. However, the molecular mechanisms of ovarian cancer progression are still unclear. circular RNAs (circRNAs) are recently reported to be involved in cancer progression regulation but the potential functions of circRNAs in ovarian cancer remains unknown. In this study, we explored the expression of circKIF4A in ovarian cancer tissues. Then, a series of experiments were conducted to investigate how circKIF4A functioned in ovarian cancer in vitro and in vivo . The results revealed that circKIF4A was highly expressed in ovarian cancer tissues. Knockdown of circKIF4A suppressed cell proliferation and migration in ovarian cancer. Subsequent mechanism study revealed that circKIF4A acted as a competitive endogenous RNA (ceRNA) to promoted ovarian cancer progression by sponging miR-127 and upregulated the expression of Junctional adhesion molecule 3 (JAM3). Therefore, circKIF4A could be a novel biomarker and therapeutic target for ovarian cancer.

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