Influences of TP53 and the anti-aging DDR1 receptor in controlling Raf/MEK/ERK and PI3K/Akt expression and chemotherapeutic drug sensitivity in prostate cancer cell lines | Zendy

William H. Chappell | Zendy; Saverio Candido | Zendy; Stephen L. Abrams | Zendy; Shaw M. Akula | Zendy; Linda S. Steelman | Zendy; Alberto M. Martelli | Zendy; Stefano Ratti | Zendy; Lucio Cocco | Zendy; Melchiorre Cervello | Zendy; Giuseppe Montalto | Zendy; Ferdinando Nicoletti | Zendy; Massimo Libra | Zendy; James A. McCubrey | Zendy

Open Access

Influences of TP53 and the anti-aging DDR1 receptor in controlling Raf/MEK/ERK and PI3K/Akt expression and chemotherapeutic drug sensitivity in prostate cancer cell lines

Author(s) -

William H. Chappell,

Saverio Candido,

Stephen L. Abrams,

Shaw M. Akula,

Linda S. Steelman,

Alberto M. Martelli,

Stefano Ratti,

Lucio Cocco,

Melchiorre Cervello,

Giuseppe Montalto,

Ferdinando Nicoletti,

Massimo Libra,

James A. McCubrey

Publication year - 2020

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.103377

Subject(s) - mapk/erk pathway , protein kinase b , pi3k/akt/mtor pathway , cancer research , prostate cancer , ddr1 , sensitivity (control systems) , chemistry , receptor , cancer , medicine , signal transduction , receptor tyrosine kinase , biochemistry , electronic engineering , engineering

TP53 plays critical roles in sensitivity to chemotherapy, and aging. Collagen is very important in aging. The molecular structure and biochemical properties of collagen changes during aging. The discoidin domain receptor (DDR1) is regulated in part by collagen. Elucidating the links between TP53 and DDR1 in chemosensitivity and aging could improve therapies against cancer and aging.

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