Attenuation of doxorubicin-induced cardiotoxicity by cryptotanshinone detected through association analysis of transcriptomic profiling and KEGG pathway | Zendy

Le Li | Zendy; Bin Wu | Zendy; Qiangqiang Zhao | Zendy; Jian Li | Zendy; Yunfeng Han | Zendy; Xiaohang Fan | Zendy; Junli Dong | Zendy; Pengcheng Li | Zendy

Open Access

Attenuation of doxorubicin-induced cardiotoxicity by cryptotanshinone detected through association analysis of transcriptomic profiling and KEGG pathway

Author(s) -

Le Li,

Bin Wu,

Qiangqiang Zhao,

Jian Li,

Yunfeng Han,

Xiaohang Fan,

Junli Dong,

Pengcheng Li

Publication year - 2020

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.103228

Subject(s) - cardiotoxicity , kegg , doxorubicin , profiling (computer programming) , transcriptome , computational biology , chemistry , medicine , biology , computer science , gene , biochemistry , toxicity , gene expression , chemotherapy , operating system

The cardiotoxicity of doxorubicin (DOX) reduces the quality of life and prognosis of cancer patients, and therefore its clinical application has been largely restricted. This study aimed to assess the effects of cryptotanshione (CPT) on DOX-induced rat cardiac insufficiency.

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