Mitochondria-related miR-574 reduces sperm ATP by targeting ND5 in aging males | Zendy

Jinzhao Ma | Zendy; Qiwei Chen | Zendy; Shuxian Wang | Zendy; Rujun Ma | Zendy; Jun Jing | Zendy; Yang� Yang | Zendy; Yuming Feng | Zendy; Zhichuan Zou | Zendy; Yu Zhang | Zendy; Xie Ge | Zendy; Tongmin Xue | Zendy; Kuan Liang | Zendy; Siyuan Cao | Zendy; Dandan Wang | Zendy; Li Chen | Zendy; Bing Yao | Zendy

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Mitochondria-related miR-574 reduces sperm ATP by targeting ND5 in aging males

Author(s) -

Jinzhao Ma,

Qiwei Chen,

Shuxian Wang,

Rujun Ma,

Jun Jing,

Yang� Yang,

Yuming Feng,

Zhichuan Zou,

Yu Zhang,

Xie Ge,

Tongmin Xue,

Kuan Liang,

Siyuan Cao,

Dandan Wang,

Li Chen,

Bing Yao

Publication year - 2020

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.103141

Subject(s) - sperm , downregulation and upregulation , mitochondrion , biology , reproduction , sperm motility , andrology , motility , oocyte , function (biology) , microbiology and biotechnology , genetics , gene , medicine , embryo

Couples are delaying childbearing in recent decades. While women experience a notable decrease in oocyte production in their late thirties, the effect of advanced paternal age on reproduction is incompletely understood. Herein, we observed that numerous miRNAs, including miR-574, increased in the sperm of aging males, as indicated by high-throughput sequencing. We demonstrated that miR-574 was upregulated in the sperm of two aging mouse models and was related to inferior sperm motility as an adverse predictor. Moreover, we proved that miR-574 suppressed mitochondrial function and reduced cellular ATP production in GC2 cells. Mechanistically, we demonstrated that miR-574 regulated mitochondrial function by directly targeting mt-ND5. Our study revealed an important role of miR-574 in sperm function in aging males and provided a fresh view to comprehend the aging process in sperm.

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