Identification of HMG-box family establishes the significance of SOX6 in the malignant progression of glioblastoma | Zendy

Lan Jiang | Zendy; Hui Yang | Zendy; Tianbing Chen | Zendy; Xiaolong Zhu | Zendy; Jingjing Ye | Zendy; Kun Lv | Zendy

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Identification of HMG-box family establishes the significance of SOX6 in the malignant progression of glioblastoma

Author(s) -

Lan Jiang,

Hui Yang,

Tianbing Chen,

Xiaolong Zhu,

Jingjing Ye,

Kun Lv

Publication year - 2020

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.103127

Subject(s) - biology , hox gene , gene , transcriptome , high mobility group , transcription factor , cancer research , genetics , gene expression

Glioblastoma multiforme (GBM) is the most malignant neuroepithelial primary brain tumor and its mean survival time is 15 months after diagnosis. This study undertook to investigate the genome-wide and transcriptome-wide analyses of human high mobility group box (HMG-box) TF (transcript factor) families / HOX, TOX, FOX, HMG and SOX gene families, and their relationships to GBM. According to the TCGA-GBM profile analysis, differentially expressed HOX, FOX, HMG and SOX gene families (62 DEmRNA) were found in this study. We also analyzed DEmRNA (HMG-box related genes) co-expressed eight DElncRNA in GBM, and constructed a ceRNA network analysis as well. We constructed 50 DElncRNA-DEmiRNA-DEmRNA (HMG-box related genes) pairs between GBM and normal tissues. Then, risk genes SOX6 and SOX21 expression were correlated with immune infiltration levels in GBM. SOX6 also had a strong association with MAPT, GSK3B, FYN and DPYSL4, suggesting that they might be functional members in GBM.

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