c-Mpl and TPO expression in the human central nervous system neurons inhibits neuronal apoptosis | Zendy

Liang Li | Zendy; Chenju Yi | Zendy; Wenjie Xia | Zendy; Bihui Huang | Zendy; Shichao Chen | Zendy; Junyan Zhong | Zendy; Xiaoyi Fang | Zendy; Liuming Yang | Zendy; Hong-Wu Xin | Zendy; Shiying Silvia Zheng | Zendy; Beng H. Chong | Zendy; Yongshui Fu | Zendy; Chun Chen | Zendy; Mo Yang | Zendy

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c-Mpl and TPO expression in the human central nervous system neurons inhibits neuronal apoptosis

Author(s) -

Liang Li,

Chenju Yi,

Wenjie Xia,

Bihui Huang,

Shichao Chen,

Junyan Zhong,

Xiaoyi Fang,

Liuming Yang,

Hong-Wu Xin,

Shiying Silvia Zheng,

Beng H. Chong,

Yongshui Fu,

Chun Chen,

Mo Yang

Publication year - 2020

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.103086

Subject(s) - neuroprotection , thrombopoietin , central nervous system , pi3k/akt/mtor pathway , apoptosis , signal transduction , biology , protein kinase b , microbiology and biotechnology , neuroscience , endocrinology , biochemistry , stem cell , haematopoiesis

Thrombopoietin (TPO) is a growth factor for the megakaryocytic/platelet lineage. In this study, we investigated the expression of TPO and its receptor, c-Mpl, in the human central nervous system (CNS) and their roles after a neural insult. Our results demonstrate that both TPO and c-Mpl are expressed in the neurons of the human CNS. TPO was also detected in human cerebrospinal fluid. TPO was found to be neuroprotective in hypoxic-ischemic neonatal rat brain models. In these rat models, treatment with TPO reduced brain damage and improved sensorimotor functions. In addition, TPO promoted C17.2 cell proliferation through activation of the PI3K/Akt signaling pathway. Via the Bcl-2/BAX signaling pathway, TPO exerted an antiapoptotic effect by suppressing mitochondrial membrane potentials. Taken together, our results indicate that TPO is neuroprotective in the CNS.

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