Exosomal miR-200c suppresses chemoresistance of docetaxel in tongue squamous cell carcinoma by suppressing TUBB3 and PPP2R1B | Zendy

Jun Cui | Zendy; Haiyan Wang | Zendy; Xiaohe Zhang | Zendy; Xiaodong Sun | Zendy; Jin Zhang | Zendy; Jinji Ma | Zendy

Open Access

Exosomal miR-200c suppresses chemoresistance of docetaxel in tongue squamous cell carcinoma by suppressing TUBB3 and PPP2R1B

Author(s) -

Jun Cui,

Haiyan Wang,

Xiaohe Zhang,

Xiaodong Sun,

Jin Zhang,

Jinji Ma

Publication year - 2020

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.103036

Subject(s) - microvesicles , exosome , cancer research , downregulation and upregulation , docetaxel , flow cytometry , in vivo , microrna , chemistry , transfection , epithelial–mesenchymal transition , apoptosis , cell , in vitro , cell culture , cancer , biology , medicine , microbiology and biotechnology , gene , biochemistry , genetics

Chemoresistance is the main challenge for treating tongue squamous cell carcinoma (TSCC). MiR-200c is an important regulator of chemoresistance. Exosomes are a promising molecule-delivery system for cancer treatment. Thus, this study aimed to investigate the role of miR-200c in chemoresistance of TSCC and whether exosomes could effectively deliver miR-200c to chemo-resistant cells and regulate cellular activities.

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