USF1-mediated upregulation of lncRNA GAS6-AS2 facilitates osteosarcoma progression through miR-934/BCAT1 axis | Zendy

Guojun Wei | Zendy; Tianwei Zhang | Zendy; Zongguang Li | Zendy; Naichun Yu | Zendy; Xiang Xue | Zendy; Daguo Zhou | Zendy; Yongjie Chen | Zendy; Linlin Zhang | Zendy; Xiaoli Yao | Zendy; Guangrong Ji | Zendy

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USF1-mediated upregulation of lncRNA GAS6-AS2 facilitates osteosarcoma progression through miR-934/BCAT1 axis

Author(s) -

Guojun Wei,

Tianwei Zhang,

Zongguang Li,

Naichun Yu,

Xiang Xue,

Daguo Zhou,

Yongjie Chen,

Linlin Zhang,

Xiaoli Yao,

Guangrong Ji

Publication year - 2020

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.103015

Subject(s) - gas6 , downregulation and upregulation , gene knockdown , cancer research , carcinogenesis , osteosarcoma , cell growth , long non coding rna , biology , apoptosis , tumor progression , cancer , medicine , gene , microbiology and biotechnology , signal transduction , genetics , receptor tyrosine kinase

Long noncoding RNAs (lncRNAs) have been certified as important regulators in tumorigenesis. LncRNA GAS6-AS2 (GAS6-AS2) was a newly identified tumor-related lncRNA, and its dysregulation and oncogenic effects in melanoma and bladder cancer had been reported in previous studies. However, the expression pattern and potential function of GAS6-AS2 in osteosarcoma (OS) have not been investigated. In this study, we identified a novel OS-related lncRNA GAS6-AS2. We found that GAS6-AS2 was distinctly upregulated in both OS specimens and cell lines. Distinct up-regulation of GAS6-AS2 in OS was correlated with advanced clinical stages and shorter survivals. In addition, USF1 could directly bind to the GAS6-AS2 promoter and contribute to its overexpression. Furthermore, GAS6-AS2 knockdown caused tumor suppressive effects via reducing cellular proliferation, migration and invasion, and promoting OS cell apoptosis. Besides, GAS6-AS2 directly bound to miR-934 and downregulated its expression. Mechanistically, GAS6-AS2 positively regulated the expression of BCAT1 through sponging miR-934. Taken together, our data illustrated how GAS6-AS2 played an oncogenic role in OS and might offer a potential therapeutic target for treating OS.

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