CEACAM1 promotes vascular aging processes

stroke are the leading cause of mortality and morbidity worldwide. Increasing age is an independent risk factor for these diseases. Therefore, therapeutic manipulation of mechanisms that lead to age-dependent pathological vascular alterations like increased intimal thickening, vascular stiffness and enhanced vascular inflammation would be a promising way in order to prevent cardiovascular events. Many pathways involved in these agerelated processes are characterized. However, most of them are not suitable targets for pharmaceutical manipulation since their inhibition causes significant adverse effects. Therefore, novel targets are required to modulate age-dependent processes.