Resilience, disease and the age of single cell science

chymal transition (EndMT) at the center of numerous pathological conditions from atherosclerosis to pulmonary hypertension, renal dysfunction and vascular malformations among others [1, 2]. Importantly, similar changes have been observed in the aging vasculature and may play an important role in the aging process itself [3]. The primary trigger of EndMT is chronic vascular inflammation that leads to activation of endothelial TGF signaling that, in turns, promotes activation of the EndMT transcriptional program. Once triggered, EndMT becomes self-sustaining, gradually driving disease (or aging) forward even if the initial trigger has been removed [4].