Berberine promotes XIAP-mediated cells apoptosis by upregulation of miR-24-3p in acute lymphoblastic leukemia | Zendy

Jian Liu | Zendy; Zhiwei Chen | Zendy; Yun-Ping Cui | Zendy; Huixia Wei | Zendy; Zhenjing Zhu | Zendy; Fengxia Mao | Zendy; Yingchao Wang | Zendy; Yufeng Liu | Zendy

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Berberine promotes XIAP-mediated cells apoptosis by upregulation of miR-24-3p in acute lymphoblastic leukemia

Author(s) -

Jian Liu,

Zhiwei Chen,

Yun-Ping Cui,

Huixia Wei,

Zhenjing Zhu,

Fengxia Mao,

Yingchao Wang,

Yufeng Liu

Publication year - 2020

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.102813

Subject(s) - xiap , apoptosis , cancer research , chemistry , tunel assay , inhibitor of apoptosis , leukemia , downregulation and upregulation , viability assay , biology , programmed cell death , immunology , caspase , gene , biochemistry

Berberine (BBR) has gained considerable attention because of its anti-tumor activity. BBR can induce apoptosis of acute lymphoblastic leukemia (ALL) cells through the MDM2/p53 pathway. However, the effects of BBR on those ALL patients with p53 deficiency remain unclear.

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