MTDH promotes metastasis of clear cell renal cell carcinoma by activating SND1-mediated ERK signaling and epithelial-mesenchymal transition | Zendy

Anbang He | Zendy; Shiming He | Zendy; Cong Huang | Zendy; Zhicong Chen | Zendy; Yucai Wu | Zendy; Yanqing Gong | Zendy; Xuesong Li | Zendy; Liqun Zhou | Zendy

Open Access

MTDH promotes metastasis of clear cell renal cell carcinoma by activating SND1-mediated ERK signaling and epithelial-mesenchymal transition

Author(s) -

Anbang He,

Shiming He,

Cong Huang,

Zhicong Chen,

Yucai Wu,

Yanqing Gong,

Xuesong Li,

Liqun Zhou

Publication year - 2020

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.102694

Subject(s) - epithelial–mesenchymal transition , cancer research , metastasis , mesenchymal stem cell , mapk/erk pathway , cell , chemistry , signal transduction , microbiology and biotechnology , medicine , biology , cancer , biochemistry

Metastasis is the principal cause of renal cell carcinoma-associated mortality. Metadherin (MTDH) was identified as a vital metastasis driver involved in the metastatic progression of various types of tumors, suggesting that MTDH is a prognostic metastatic biomarker and potential therapeutic target. The role and mechanism of MTDH in the metastatic progression of ccRCC have not yet been adequately explored.

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