Open AccessUp-regulation of microRNA-375 ameliorates the damage of dopaminergic neurons, reduces oxidative stress and inflammation in Parkinson’s disease by inhibiting SP1
Author(s) -
Lijun Cai,
Li Tu,
Li Tian,
Xiulin Yang,
Yipin Ren,
Ran Gu,
Qian Zhang,
Huan Yao,
Xiang Qu,
Qian Wang,
Jinyong Tian
Publication year - 2020
Publication title -
aging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 90
ISSN - 1945-4589
DOI - 10.18632/aging.102649
Subject(s) - substantia nigra , dopaminergic , oxidative stress , parkinson's disease , dopamine , striatum , inflammation , medicine , endocrinology , chemistry , pharmacology , disease
This study is conducted to investigate the protective role of elevated microRNA-375 (miR-375) in dopaminergic neurons in Parkinson's disease through down-regulating transcription factor specificity protein 1 (SP1).
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