Stimulation of MMP-9 of oral epithelial cells by areca nut extract is related to TGF-β/Smad2-dependent and –independent pathways and prevented by betel leaf extract, hydroxychavicol and melatonin | Zendy

Mei-Chi Chang | Zendy; Yu-Hwa Pan | Zendy; HsyuehLiang Wu | Zendy; YiJie Lu | Zendy; Wan-Chuen Liao | Zendy; Chien-Yang Yeh | Zendy; JangJaer Lee | Zendy; JiiangHuei Jeng | Zendy

Open Access

Stimulation of MMP-9 of oral epithelial cells by areca nut extract is related to TGF-β/Smad2-dependent and –independent pathways and prevented by betel leaf extract, hydroxychavicol and melatonin

Author(s) -

Mei-Chi Chang,

Yu-Hwa Pan,

HsyuehLiang Wu,

YiJie Lu,

Wan-Chuen Liao,

Chien-Yang Yeh,

JangJaer Lee,

JiiangHuei Jeng

Publication year - 2019

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.102565

Subject(s) - areca , melatonin , nut , betel , stimulation , matrix metalloproteinase , traditional medicine , biology , medicine , pharmacology , structural engineering , engineering

There are 200-600 million betel quid (BQ) chewers in the world. BQ increases oral cancer risk. Matrix metalloproteinase-9 (MMP-9) is responsible for matrix degradation, cancer invasion and metastasis. Whether areca nut extract (ANE), a BQ component, stimulates MMP-9 secretion, and the related signaling pathways awaits investigation.

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