Astaxanthin protects against osteoarthritis via Nrf2: a guardian of cartilage homeostasis | Zendy

Kai Sun | Zendy; Jiahui Luo | Zendy; Xingzhi Jing | Zendy; Jiachao Guo | Zendy; Xudong Yao | Zendy; Xiaoxia Hao | Zendy; Yaping Ye | Zendy; Shuang Liang | Zendy; Jiamin Lin | Zendy; Genchun Wang | Zendy; Fengjing Guo | Zendy

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Astaxanthin protects against osteoarthritis via Nrf2: a guardian of cartilage homeostasis

Author(s) -

Kai Sun,

Jiahui Luo,

Xingzhi Jing,

Jiachao Guo,

Xudong Yao,

Xiaoxia Hao,

Yaping Ye,

Shuang Liang,

Jiamin Lin,

Genchun Wang,

Fengjing Guo

Publication year - 2019

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.102474

Subject(s) - chondrocyte , oxidative stress , cartilage , osteoarthritis , apoptosis , chemistry , microbiology and biotechnology , homeostasis , inflammation , pharmacology , signal transduction , medicine , cancer research , biochemistry , biology , pathology , anatomy , alternative medicine

Osteoarthritis (OA) is a progressive disease characterized by cartilage degradation. Astaxanthin (Ast), a natural compound with remarkable antioxidant activity and multiple medical applications due to its activation of Nrf2 signaling, has been studied for application to various degenerative diseases. Currently, however, little is known about its efficacy in treating OA. This study reports the effects of Ast on cartilage homeostasis in OA progression.

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