LHX2 promotes malignancy and inhibits autophagy via mTOR in osteosarcoma and is negatively regulated by miR-129-5p | Zendy

Honghai Song | Zendy; JiaMing Liu | Zendy; Xin Wu | Zendy; Yang Zhou | Zendy; Xuanyin Chen | Zendy; Jiangwei Chen | Zendy; KeYu Deng | Zendy; Chunxia Mao | Zendy; Shan-Hu Huang | Zendy; Zhili Liu | Zendy

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LHX2 promotes malignancy and inhibits autophagy via mTOR in osteosarcoma and is negatively regulated by miR-129-5p

Author(s) -

Honghai Song,

JiaMing Liu,

Xin Wu,

Yang Zhou,

Xuanyin Chen,

Jiangwei Chen,

KeYu Deng,

Chunxia Mao,

Shan-Hu Huang,

Zhili Liu

Publication year - 2019

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.102427

Subject(s) - autophagy , pi3k/akt/mtor pathway , osteosarcoma , gene silencing , cancer research , malignancy , carcinogenesis , rptor , biology , chemistry , signal transduction , cancer , microbiology and biotechnology , gene , apoptosis , genetics

The transcript factor LHX2 is dysregulated in many cancers but its role in osteosarcoma (OS) remains unclear. In this study, we confirm that LHX2 is up-regulated in osteosarcoma, and that its silencing inhibits OS malignancy and induces autophagy via mTOR signaling. We further demonstrate that miR-129-5p negatively regulates LHX2 and suppresses the malignant phenotypes of OS. LHX2 overexpression could restore the malignant phenotypes. In conclusion, LHX2 regulates tumorigenesis and autophagy via mTOR in OS and is negatively regulated by miR-129-5p. Targeting the miR-129-5p/LHX2/mTOR axis therefore represents a novel therapeutic strategy for OS treatment.

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