Tanshinone IIA mediates SMAD7-YAP interaction to inhibit liver cancer growth by inactivating the transforming growth factor beta signaling pathway | Zendy

Lifang Ma | Zendy; Hongyuan Jiang | Zendy; Xin Xu | Zendy; Congcong Zhang | Zendy; Yongjie Niu | Zendy; Zhixian Wang | Zendy; Yuquan Tao | Zendy; Yan Li | Zendy; Feng Cai | Zendy; Xiao Zhang | Zendy; Xinghe Wang | Zendy; Yongchun Yu | Zendy

Open Access

Tanshinone IIA mediates SMAD7-YAP interaction to inhibit liver cancer growth by inactivating the transforming growth factor beta signaling pathway

Author(s) -

Lifang Ma,

Hongyuan Jiang,

Xin Xu,

Congcong Zhang,

Yongjie Niu,

Zhixian Wang,

Yuquan Tao,

Yan Li,

Feng Cai,

Xiao Zhang,

Xinghe Wang,

Yongchun Yu

Publication year - 2019

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.102420

Subject(s) - salvia miltiorrhiza , transforming growth factor beta , cell growth , cancer research , transforming growth factor , apoptosis , liver cancer , cancer , signal transduction , cancer cell , chemistry , microbiology and biotechnology , pharmacology , biology , medicine , traditional chinese medicine , biochemistry , hepatocellular carcinoma , pathology , alternative medicine

Tanshinone IIA (TanIIA)-an active constituent of Salvia miltiorrhiza , a traditional Chinese medicinal plant-is known to have blood circulation promotion and anti-tumor properties. Tan IIA can induce tumor cell death and inhibit tumor growth. However, the functions and underling molecular mechanisms of Tan IIA action on human liver cancer cells remain poorly understand. In this study, we found that Tanshinone IIA mediates SMAD7-YAP interaction to induce liver cancer cell apoptosis and inhibit cell growth and migration by inactivating the transforming growth factor beta (TGF-β) signaling pathway. Our findings showed that the Tan IIA-SMAD7-YAP regulatory network might be an effective strategy for liver cancer treatment.

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