Open AccessLoss of FoxA2 accelerates neoplastic changes in the intrahepatic bile duct partly via the MAPK signaling pathway
Author(s) -
Junyi Shen,
Yongjie Zhou,
Xiaoyun Zhang,
Wei Peng,
Chihan Peng,
Qiang Zhou,
Chuan Li,
Tianfu Wen,
Yujun Shi
Publication year - 2019
Publication title -
aging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 90
ISSN - 1945-4589
DOI - 10.18632/aging.102332
Subject(s) - foxa2 , mapk/erk pathway , cancer research , western blot , intrahepatic cholangiocarcinoma , bile duct diseases , signal transduction , bile duct , biology , immunohistochemistry , gene silencing , medicine , transcription factor , gene , microbiology and biotechnology , genetics
Intrahepatic cholangiocarcinoma (ICC) is characterized by a highly aggressive nature and a dismal outcome. FOXA2 is an archetypal transcription factor involved in cholangiocyte proliferation.
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