ACADS acts as a potential methylation biomarker associated with the proliferation and metastasis of hepatocellular carcinomas | Zendy

Diyu Chen | Zendy; Xiaode Feng | Zendy; Zhen Lv | Zendy; Xiaofeng Xu | Zendy; Yuejie Lu | Zendy; Wenxuan Wu | Zendy; Hao Wu | Zendy; Hua Liu | Zendy; Linping Cao | Zendy; Sunyi Ye | Zendy; Jianzhong Chen | Zendy; Jian Wu | Zendy

Open Access

ACADS acts as a potential methylation biomarker associated with the proliferation and metastasis of hepatocellular carcinomas

Author(s) -

Diyu Chen,

Xiaode Feng,

Zhen Lv,

Xiaofeng Xu,

Yuejie Lu,

Wenxuan Wu,

Hao Wu,

Hua Liu,

Linping Cao,

Sunyi Ye,

Jianzhong Chen,

Jian Wu

Publication year - 2019

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.102292

Subject(s) - biology , hepatocellular carcinoma , biomarker , dna methylation , cancer research , gene knockdown , metastasis , cancer , function (biology) , methylation , gene expression , gene , genetics

Hepatocellular carcinomas (HCC) constantly rank among the malignancies with the highest death tolls on the global scale. Moreover, HCC are associated with a limited set of therapeutic options. This is particularly true in the case of advanced stage cancers, where long-term survival is uncommon. For the inoperable, advanced HCC patients, chemotherapy is the main modality of treatment. Due to the lack of known molecular targets, the efficacy of the chemotherapy is limited.

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