Upregulation of miR-93 and inhibition of LIMK1 improve ventricular remodeling and alleviate cardiac dysfunction in rats with chronic heart failure by inhibiting RhoA/ROCK signaling pathway activation | Zendy

Qian Su | Zendy; Peng Zhang | Zendy; Yu Dong | Zendy; Zhaodi Wu | Zendy; Dandan Li | Zendy; Fangfang Shen | Zendy; Pengfei Liao | Zendy; Guizhi Yin | Zendy

Open Access

Upregulation of miR-93 and inhibition of LIMK1 improve ventricular remodeling and alleviate cardiac dysfunction in rats with chronic heart failure by inhibiting RhoA/ROCK signaling pathway activation

Author(s) -

Qian Su,

Peng Zhang,

Yu Dong,

Zhaodi Wu,

Dandan Li,

Fangfang Shen,

Pengfei Liao,

Guizhi Yin

Publication year - 2019

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.102272

Subject(s) - rhoa , downregulation and upregulation , rock1 , heart failure , medicine , oxidative stress , microrna , signal transduction , microbiology and biotechnology , cancer research , chemistry , biology , gene , biochemistry

There are some researches about the role of microRNA (miRNA) in chronic heart failure (CHF) were performed, but the study about miR-93's function in CHF is scarcely investigated. Thus, we determined to probe into the effects of miR-93 in rats with CHF by targeting LIMK1 through regulating RhoA/ROCK pathway.

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