Ketones improves Apolipoprotein E4-related memory deficiency via sirtuin 3 | Zendy

Junxiang Yin | Zendy; Megan Nielsen | Zendy; Shiping Li | Zendy; Jiong Shi | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Ketones improves Apolipoprotein E4-related memory deficiency via sirtuin 3

Author(s) -

Junxiang Yin,

Megan Nielsen,

Shiping Li,

Jiong Shi

Publication year - 2019

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.102070

Subject(s) - sirt3 , endocrinology , medicine , sirtuin , genetically modified mouse , hippocampus , neuroprotection , nad+ kinase , apolipoprotein e , memory consolidation , ketone bodies , neurodegeneration , chemistry , transgene , biology , biochemistry , metabolism , enzyme , disease , gene

Apolipoprotein E4 (ApoE4) is the major genetic risk factor of Alzheimer's disease (AD). ApoE4 carriers have cerebral hypometabolism which is thought as a harbinger of AD. Our previous studies indicated ketones improved mitochondria energy metabolism via sirtuin 3 (Sirt3). However, it is unclear whether ketones upregulate Sirt3 and improve ApoE4-related learning and memory deficits.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research