Mitofusin 2 plays a role in oocyte and follicle development, and is required to maintain ovarian follicular reserve during reproductive aging | Zendy

Man Zhang | Zendy; Muhammed Burak Bener | Zendy; Zongliang Jiang | Zendy; Tianren Wang | Zendy; Ecem Esencan | Zendy; Richard Scott | Zendy; Tamas L. Horváth | Zendy; Emre Seli | Zendy

Open Access

Mitofusin 2 plays a role in oocyte and follicle development, and is required to maintain ovarian follicular reserve during reproductive aging

Author(s) -

Man Zhang,

Muhammed Burak Bener,

Zongliang Jiang,

Tianren Wang,

Ecem Esencan,

Richard Scott,

Tamas L. Horváth,

Emre Seli

Publication year - 2019

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.102024

Subject(s) - mfn2 , oocyte , follicular phase , ovarian follicle , mitochondrial fusion , microbiology and biotechnology , biology , ovarian reserve , andrology , mitochondrion , folliculogenesis , medicine , endocrinology , mitochondrial dna , embryo , genetics , embryogenesis , pregnancy , gene , infertility

Mitochondria change their shape through fusion and fission in order to adapt to their metabolic milieu. Mitofusin-2 (MFN2) is a key regulatory protein in this process, mediating mitochondrial fusion and interaction with endoplasmic reticulum. Targeted deletion of Mfn2 in oocytes resulted in mitochondrial dysfunction and female subfertility associated with impaired oocyte maturation and follicle development. Oocytes lacking MFN2 showed shortened telomeres and increased apoptosis, resulting in compromised oocyte quality and accelerated follicular depletion, consistent with a reproductive aging phenotype.

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