Fluoxetine-mediated inhibition of endoplasmic reticulum stress is involved in the neuroprotective effects of Parkinson’s disease | Zendy

Tao Peng | Zendy; Xiaoyan Liu | Zendy; Jingtao Wang | Zendy; Yu Liu | Zendy; Zhenqiang Fu | Zendy; Xingrong Ma | Zendy; Junmin Li | Zendy; Guifang Sun | Zendy; Yangfei Ji | Zendy; Jingjing Lu | Zendy; Wencui Wan | Zendy; Hong Lü | Zendy

Open Access

Fluoxetine-mediated inhibition of endoplasmic reticulum stress is involved in the neuroprotective effects of Parkinson’s disease

Author(s) -

Tao Peng,

Xiaoyan Liu,

Jingtao Wang,

Yu Liu,

Zhenqiang Fu,

Xingrong Ma,

Junmin Li,

Guifang Sun,

Yangfei Ji,

Jingjing Lu,

Wencui Wan,

Hong Lü

Publication year - 2018

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.101716

Subject(s) - neuroprotection , rotenone , neurodegeneration , dopaminergic , pharmacology , catalepsy , parkinson's disease , endoplasmic reticulum , unfolded protein response , medicine , dopamine , endocrinology , chemistry , mitochondrion , biochemistry , disease , haloperidol

Accumulating evidence suggests that Fluoxetine (FLX), an anti-depressant drug, has broad neurobiological functions and neuroprotective effects in central nervous system injury, but its roles in Parkinson's disease (PD) remain unclear. In this study, we aimed to evaluate whether fluoxetine attenuates rotenone-induced neurodegeneration in PD.

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