Origin and pathophysiology of protein carbonylation, nitration and chlorination in age-related brain diseases and aging | Zendy

Efstathios S. Gonos | Zendy; Μαριάννα Καπετάνου | Zendy; Jolanta Sereikaitė | Zendy; Grzegorz Bartosz | Zendy; Katarzyparło | Zendy; Michalina Grzesik | Zendy; Izabela SadowskaBartosz | Zendy

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Origin and pathophysiology of protein carbonylation, nitration and chlorination in age-related brain diseases and aging

Author(s) -

Efstathios S. Gonos,

Μαριάννα Καπετάνου,

Jolanta Sereikaitė,

Grzegorz Bartosz,

Katarzyparło,

Michalina Grzesik,

Izabela SadowskaBartosz

Publication year - 2018

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.101450

Subject(s) - nitration , protein carbonylation , carbonylation , brain aging , chemistry , ageing , biochemistry , biology , enzyme , neuroscience , organic chemistry , carbon monoxide , oxidative damage , catalysis , cognition , genetics

Non-enzymatic protein modifications occur inevitably in all living systems. Products of such modifications accumulate during aging of cells and organisms and may contribute to their age-related functional deterioration. This review presents the formation of irreversible protein modifications such as carbonylation, nitration and chlorination, modifications by 4-hydroxynonenal, removal of modified proteins and accumulation of these protein modifications during aging of humans and model organisms, and their enhanced accumulation in age-related brain diseases.

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