KCNQ1OT1 promotes melanoma growth and metastasis | Zendy

Bingyu Guo | Zendy; Qian Zhang | Zendy; Hongyi Wang | Zendy; Peng Chang | Zendy; Kai Tao | Zendy

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KCNQ1OT1 promotes melanoma growth and metastasis

Author(s) -

Bingyu Guo,

Qian Zhang,

Hongyi Wang,

Peng Chang,

Kai Tao

Publication year - 2018

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.101418

Subject(s) - melanoma , competing endogenous rna , metastasis , cancer research , long non coding rna , distant metastasis , biology , microrna , endogeny , neoplasm , rna , cancer , medicine , gene , genetics

Melanoma is the deadliest cutaneous neoplasm. To prevent metastasis, early diagnosis and surgical treatment is vital. Long non-coding RNAs (lncRNAs) may serve as biomarkers and therapeutic targets in tumors. We investigated the molecular mechanisms of lncRNA KCNQ1OT1 in melanoma. Real time PCR demonstrated that KCNQ1OT1 expression is up-regulated in melanoma tissues and cells. KCNQ1OT1 promoted cell proliferation and metastasis in melanoma. By directly bindin to miR-153, KCNQ1OT1 acted as a competing endogenous RNA (ceRNA) to de-repress MET expression. Our results may provide the basis for a novel strategy for early detection and/or treatment of melanoma.

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