The role of hydrogen sulfide in aging and age-related pathologies | Zendy

Bernard W. Perridon | Zendy; Henri G. D. Leuvenink | Zendy; JanLuuk Hillebrands | Zendy; Harry van Goor | Zendy; Eelke M. Bos | Zendy

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The role of hydrogen sulfide in aging and age-related pathologies

Author(s) -

Bernard W. Perridon,

Henri G. D. Leuvenink,

JanLuuk Hillebrands,

Harry van Goor,

Eelke M. Bos

Publication year - 2016

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.101026

Subject(s) - hydrogen sulfide , ageing , neuroscience , senescence , biology , microbiology and biotechnology , chemistry , genetics , sulfur , organic chemistry

When humans grow older, they experience inevitable and progressive loss of physiological function, ultimately leading to death. Research on aging largely focuses on the identification of mechanisms involved in the aging process. Several proposed aging theories were recently combined as the 'hallmarks of aging'. These hallmarks describe (patho-)physiological processes that together, when disrupted, determine the aging phenotype. Sustaining evidence shows a potential role for hydrogen sulfide (H 2 S) in the regulation of aging. Nowadays, H 2 S is acknowledged as an endogenously produced signaling molecule with various (patho-) physiological effects. H 2 S is involved in several diseases including pathologies related to aging. In this review, the known, assumed and hypothetical effects of hydrogen sulfide on the aging process will be discussed by reviewing its actions on the hallmarks of aging and on several age-related pathologies.

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