Markers of cellular senescence. Telomere shortening as a marker of cellular senescence | Zendy

Alexandra Bernadotte | Zendy; Victor M. Mikhelson | Zendy; Spivak Im | Zendy

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Markers of cellular senescence. Telomere shortening as a marker of cellular senescence

Author(s) -

Alexandra Bernadotte,

Victor M. Mikhelson,

Spivak Im

Publication year - 2016

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.100871

Subject(s) - senescence , telomere , cellular senescence , cellular aging , biology , microbiology and biotechnology , cellular model , cell , in vitro , phenotype , genetics , dna , gene

The cellular senescence definition comes to the fact of cells irreversible proliferation disability. Besides the cell cycle arrest, senescent cells go through some morphological, biochemical, and functional changes which are the signs of cellular senescence. The senescent cells (including replicative senescence and stress-induced premature senescence) of all the tissues look alike. They are metabolically active and possess the set of characteristics in vitro and in vivo, which are known as biomarkers of aging and cellular senescence. Among biomarkers of cellular senescence telomere shortening is a rather elegant frequently used biomarker. Validity of telomere shortening as a marker for cellular senescence is based on theoretical and experimental data.

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