ARF: Connecting senescence and innate immunity for clearance | Zendy

Alper Y. Kearney | Zendy; Benedict Anchang | Zendy; Sylvia K. Plevritis | Zendy; Dean W. Felsher | Zendy

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ARF: Connecting senescence and innate immunity for clearance

Author(s) -

Alper Y. Kearney,

Benedict Anchang,

Sylvia K. Plevritis,

Dean W. Felsher

Publication year - 2015

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.100813

Subject(s) - innate immune system , senescence , immunity , biology , cellular senescence , microbiology and biotechnology , oncogene , immune system , immunology , cancer research , gene , genetics , cell cycle , phenotype

We have found evidence suggesting that ARF and p53 are essential for tumor regression upon MYC inactivation through distinct mechanisms ARF through p53-independent affect, is required to for MYC to regulate the expression of genes that are required for both the induction of cellular senescence as well as recruitment of innate immune activation. Our observations have possible implications for mechanisms of therapeutic resistance to targeted oncogene inactivation.

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