Defective mitochondrial respiration, altered dNTP pools and reduced AP endonuclease 1 activity in peripheral blood mononuclear cells of Alzheimer's disease patients | Zendy

Scott Maynard | Zendy; AnneMette Hejl | Zendy; Thuan-Son T. Dinh | Zendy; Guido Keijzers | Zendy; Åse Marie Hansen | Zendy; Claus Desler | Zendy; María MorenoVillanueva | Zendy; Alexander Bürkle | Zendy; Lene Juel Rasmussen | Zendy; Gunhild Waldemar | Zendy; Vilhelm A. Bohr | Zendy

Open Access

Defective mitochondrial respiration, altered dNTP pools and reduced AP endonuclease 1 activity in peripheral blood mononuclear cells of Alzheimer's disease patients

Author(s) -

Scott Maynard,

AnneMette Hejl,

Thuan-Son T. Dinh,

Guido Keijzers,

Åse Marie Hansen,

Claus Desler,

María MorenoVillanueva,

Alexander Bürkle,

Lene Juel Rasmussen,

Gunhild Waldemar,

Vilhelm A. Bohr

Publication year - 2015

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.100810

Subject(s) - peripheral blood mononuclear cell , mitochondrial dna , dna damage , mitochondrion , biology , microbiology and biotechnology , bioenergetics , dna repair , dna , biochemistry , gene , in vitro

Accurate biomarkers for early diagnosis of Alzheimer's disease (AD) are badly needed. Recent reports suggest that dysfunctional mitochondria and DNA damage are associated with AD development. In this report, we measured various cellular parameters, related to mitochondrial bioenergetics and DNA damage, in peripheral blood mononuclear cells (PBMCs) of AD and control participants, for biomarker discovery.

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